The Department of Biochemistry of the Faculty of Medicine, Wayamba University of Sri Lanka, Kuliyapitiya, serves as a fundamental academic unit within the preclinical phase of the medical curriculum, providing a comprehensive foundation for understanding the molecular basis of human health and disease. As one of the principal disciplines in early medical education, the department integrates core biochemical principles with clinical relevance, enabling students to develop a strong scientific framework essential for subsequent clinical training. Its teaching encompasses foundational concepts alongside key areas such as metabolism and nutrition, the biochemical aspects of blood and immune function, and the regulation of biochemical processes through endocrine and gastrointestinal systems, all delivered in a manner that promotes critical thinking and application to medical practice. In addition to its teaching responsibilities, the department contributes to research and academic development while supporting the broader mission of the faculty in producing competent and knowledgeable healthcare professionals.